The Fermilab E906/SeaQuest is an experiment aimed at studying the anti-quark distributions in nucleons and nuclei. The experiment uses a 120 GeV proton beam extracted from the Main Injector at Fermilab to collide with various solid and cryogenic targets to study a variety of physics topics ranging from light quark flavor asymmetry to the EMC effect in the nucleon sea. It takes advantage of the Drell-Yan process to probe the anti-quark structure. In the Drell-Yan process, a quark from one hadron annihilates with an anti-quark from another hadron, producing a virtual photon which eventually decays into a dileptons. The SeaQuest forward spectrometer is optimized for detecting such di-muons. The overall status of the experiment and recent results regarding light quark flavor asymmetry in the nucleon sea, parton energy loss in cold nuclear matter and nuclear dependence of the anti-quarks in heavy nuclei will be presented in this talk.